Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved.

ABSTRACT:

Background

The exact cause of recurrent aphthous stomatitis is still unknown, making it a challenge to develop effective treatments. This study employs computational biology to investigate the molecular basis of recurrent aphthous stomatitis, aiming to identify the nature of the stimuli triggering these ulcers and the type of cell death involved.

Methods

To understand the molecular underpinnings of recurrent aphthous stomatitis, we used the Génie tool for gene identification, targeting those associated with cell death in recurrent aphthous stomatitis. The ToppGene Suite was employed for functional enrichment analysis. We also used Reactome and InteractiVenn for protein integration and prioritization against a PANoptosis gene list, enabling the construction of a protein-prote

SUBMITTER: Riveros-Gomez I 

PROVIDER: S-EPMC11440928 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature