OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning.

ABSTRACT:

Background

Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for their function. For instance, the position of lysosomes relative to the nucleus controls their degradative capacity and is altered in pathophysiological conditions. The molecular components orchestrating the precise localization of organelles remain incompletely understood. A confounding factor in these studies is the fact that organelle positioning is surprisingly non-trivial to address e.g., perturbations that affect the localization of organelles often lead to secondary phenotypes such as changes in cell or organelle size. These phenotypes could potentially mask effe

SUBMITTER: Schmied C 

PROVIDER: S-EPMC11440938 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature