Optimization and Evaluation of Al¹⁸F Labeling Using a NOTA-or RESCA1-Conjugated AE105 Peptide Antagonist of uPAR.

ABSTRACT: Fluorine-18 displays almost ideal decay properties for positron emission tomography (PET) and allows for large scale production. As such, simplified methods to radiolabel peptides with fluorine-18 are highly warranted. Chelation of aluminium fluoride-18 toward specific peptides represents one method to achieve this. With the current methods, chelation of aluminium fluoride-18 can be achieved using NOTA-conjugated peptides. However, the heating to 90-100◦C that is required for this chelation approach may be deleterious to the targeting moiety of the probe. Recently, a new chelator, RESCA1, was developed allowing Al¹⁸F chelation at room temperature. Here, we optimize the labeling procedure enabling high chelation efficacy of fluoride-18 at 22◦C, even at full batch labeling. The op

SUBMITTER: Jeppesen TE 

PROVIDER: S-EPMC11440976 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature