Monocyte-driven inflamm-aging reduces intestinal barrier function in females.

ABSTRACT:

Background

The intestinal barrier encompasses physical and immunological components that act to compartmentalize luminal contents, such as bacteria and endotoxins, from the host. It has been proposed that an age-related decline of intestinal barrier function may allow for the passage of luminal contents into the bloodstream, triggering a low-grade systemic inflammation termed inflamm-aging. Although there is mounting evidence to support this hypothesis in model species, it is unclear if this phenomenon occurs in humans. In addition, despite being well-established that biological sex impacts aging physiology, its influence on intestinal barrier function and inflamm-aging has not been explored.

Results

In this study, we observed sex differences in markers of intestinal barrier

SUBMITTER: Quin C 

PROVIDER: S-EPMC11440997 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature