SUMOylation-induced membrane localization of TRPV1 suppresses proliferation and migration in gastric cancer cells.

ABSTRACT: Gastric cancer (GC) remains a significant health challenge due to its high mortality rate and the limited efficacy of current targeted therapies. A critical barrier in developing more effective treatments is the lack of understanding of specific mechanisms driving GC progression. This study investigates the role of Transient Receptor Potential Vanilloid 1 (TRPV1), a non-selective cation channel known for its high Ca²⁺ permeability and tumor-suppressive properties in gastrointestinal cancers. Specifically, we explore the impact of SUMOylation-a dynamic and reversible post-translational modification-on TRPV1's function in GC. We demonstrate that SUMOylation of TRPV1 inhibits cell proliferation and migration in MGC-803 and AGS GC cells. By mutating amino acids near TRPV1's existing

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11441086 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature