Obesity modulates hematopoietic stem cell fate decision via IL-1β induced p38/MAPK signaling pathway.

ABSTRACT:

Background

Obesity is accompanied by inflammation, which significantly affects the homeostasis of the immune microenvironment. Hematopoietic stem cells (HSCs), residing primarily in the bone marrow, play a vital role in maintaining and producing diverse mature blood cell lineages for the adult hematopoietic and immune systems. However, how HSCs development is affected by obese-promoting inflammation, and the mechanism by which HSC hematopoietic potency is affected by inflammatory signals originating from the obese-promoting changes on bone marrow niche remain unclear. This study elucidates the relationship between obesity-promoting inflammation and HSC fate determination.

Methods

The obesity mice model was established by feeding C57BL/6J mice a high-fat diet (HFD) containing

SUBMITTER: Yan J 

PROVIDER: S-EPMC11441115 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature