Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status.

ABSTRACT:

Background

The human gut microbiome produces and consumes a variety of compounds that interact with the host and impact health. Succinate is of particular interest as it intersects with both host and microbiome metabolism. However, which gut bacteria are most responsible for the consumption of intestinal succinate is poorly understood.

Results

We build upon an enrichment-based whole fecal sample culturing approach and identify two main bacterial taxa that are responsible for succinate consumption in the human intestinal microbiome, Phascolarctobacterium and Dialister. These two taxa have the hallmark of a functional guild and are strongly mutual exclusive across 21,459 fecal samples in 94 cohorts and can thus be used to assign a robust "succinotype" to an individual. We show

SUBMITTER: Anthamatten L 

PROVIDER: S-EPMC11441152 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature