Differential chromatin accessibility and Gene Expression Associated with Backfat Deposition in pigs.

ABSTRACT:

Background

Backfat serves as a vital fat reservoir in pigs, and its excessive accumulation will adversely impact pig growth performance, farming efficiency, and pork quality. The aim of this research is to integrate assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to explore the molecular mechanisms underlying porcine backfat deposition.

Results

ATAC-seq analysis identified 568 genes originating from 698 regions exhibiting differential accessibility, which were significantly enriched in pathways pertinent to adipocyte differentiation and lipid metabolism. Besides, a total of 283 transcription factors (TFs) were identified by motif analysis. RNA-seq analysis revealed 978 differentially expressed genes (DEGs), w

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11441165 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature