Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy.

ABSTRACT: The close relationship between Alzheimer's disease (AD) and obesity was recognized many years ago. However, complete understanding of the pathological mechanisms underlying the interactions between degeneration of CNS and fat metabolism is still missing. The leptin a key adipokine of white adipose tissue has been suggested as one of the major mediators linking the obesity and AD. Here we investigated the association between peripheral levels of leptin, general metabolic status and stage of the pathogenesis in rat transgenic model of AD. We demonstrate significantly decreased levels of plasma leptin in animals with experimentally induced progressive neurofibrillary pathology, which represents only 62.3% (P = 0.0015) of those observed in normal wild type control animals. More detailed analys

SUBMITTER: Cente M 

PROVIDER: S-EPMC11441179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature