Spinal Cord Injury Leads to Hippocampal Glial Alterations and Neural Stem Cell Inactivation.

ABSTRACT: The hippocampus encodes spatial and contextual information involved in memory and learning. The incorporation of new neurons into hippocampal networks increases neuroplasticity and enhances hippocampal-dependent learning performances. Only few studies have described hippocampal abnormalities after spinal cord injury (SCI) although cognitive deficits related to hippocampal function have been reported in rodents and even humans. The aim of this study was to characterize in further detail hippocampal changes in the acute and chronic SCI. Our data suggested that neurogenesis reduction in the acute phase after SCI could be due to enhanced death of amplifying neural progenitors (ANPs). In addition, astrocytes became reactive and microglial cells increased their number in almost all hippocampal r

SUBMITTER: Jure I 

PROVIDER: S-EPMC11441270 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature