Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life.

ABSTRACT:

Background and objectives

Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent.

Research design and methods

We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank. The early life factors (eg, maternal smoking, breastfeeding, birth weight, and comparative body size and height to peers at age 10) were measured. The regression coefficients (β) and 95% confidence interval (CI) were applied to assess the link of the early life factors and TL in adulthood. Flexible parametric survival models incorporated age

SUBMITTER: Lin F 

PROVIDER: S-EPMC11441326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature