Unveiling superior phenol detoxification and degradation ability in <i>Candida tropicalis</i> SHC-03: a comparative study with <i>Saccharomyces cerevisiae</i> BY4742.

ABSTRACT: This study examined the phenol degradation capabilities and oxidative stress responses of Candida tropicalis SHC-03, demonstrating its metabolic superiority and resilience compared to Saccharomyces cerevisiae BY4742 in a culture medium with phenol as the sole carbon source. Through comparative growth, transcriptomic, and metabolomic analyses under different phenol concentrations, this study revealed C. tropicalis SHC-03's specialized adaptations for thriving in phenol as the sole carbon source environments. These include a strategic shift from carbohydrate metabolism to enhanced phenol degradation pathways, highlighted by the significant upregulation of genes for Phenol 2-monoxygenase and Catechol 1,2-dioxygenase. Despite phenol levels reaching 1.8 g/L, C. tropicali

SUBMITTER: Li Q 

PROVIDER: S-EPMC11441332 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature