Influence of cognitive reserve on risk of depression and subsequent dementia: A large community-based longitudinal study.

ABSTRACT:

Background

Cognitive reserve (CR) has been linked to dementia, yet its influence on the risk of depression and related outcomes remains unknown. We aimed to examine the association of CR with depression and subsequent dementia or death, and to assess the extent to which CR is related to depression-free survival.

Methods

Within the UK Biobank, 436,232 participants free of depression and dementia were followed. A comprehensive CR indicator (low, moderate, and high) was created using latent class analysis based on information on education, occupation, mentally passive sedentary behavior, social connection, confiding with others, and leisure activities. Depression, dementia, and survival status were ascertained through self-reported medical history and/or linkages to medical rec

SUBMITTER: Yang W 

PROVIDER: S-EPMC11441338 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature