Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury.

ABSTRACT:

Objectives

The acute cerebral physiologic effects of ketamine in children have been incompletely described. We assessed the acute effects of ketamine on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in children with severe traumatic brain injury (TBI).

Design

In this retrospective observational study, patients received bolus doses of ketamine for sedation or as a treatment for ICP crisis (ICP > 20 mm Hg for > 5 min). Administration times were synchronized with ICP and CPP recordings at 1-minute intervals logged in an automated database within the electronic health record. ICP and CPP were each averaged in epochs following drug administration and compared with baseline values. Age-based CPP thresholds were subtracted from CPP recordings and compared with b

SUBMITTER: Laws JC 

PROVIDER: S-EPMC11441348 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature