High microvessel and lymphatic vessel density predict poor prognosis in patients with esophageal squamous cell carcinoma.

ABSTRACT:

Background

Microangiogenesis and lymphangiogenesis are essential for tumor growth in the tumor microenvironment, contributing to tumor invasion and metastasis. Limited literature exists on these processes in esophageal squamous cell carcinoma (ESCC). Therefore, the purpose of this study is to explore the impacts of microangiogenesis and lymphangiogenesis on the occurrence, progression, and prognosis assessment of ESCC.

Methods

Surgical specimens and paraffin-embedded human tissues were procured from ESCC patients, encompassing 100 ESCC tissues and 100 cancer-adjacent normal (CAN) tissues. CD34 and D2-40 were utilized as markers for microvessel endothelial cells and lymphatic vessel endothelial cells, respectively. Microvascular density (MVD) and lymphatic vessel density (LVD

SUBMITTER: Qi LW 

PROVIDER: S-EPMC11441385 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature