Exploring Scotopic Microperimetry as an Outcome Measure in Choroideremia.

ABSTRACT:

Purpose

Choroideremia is an X-linked outer retinal degeneration. Early symptoms include nyctalopia and progressive visual field loss, but visual acuity is preserved until late disease stages. Dark-adapted two-color fundus-controlled perimetry (also known as scotopic microperimetry) has been developed to enable spatial assessment of rod and cone photoreceptor function. This study explores the use of scotopic microperimetry in patients with choroideremia.

Methods

Twenty patients with choroideremia and 21 age-matched healthy controls completed visual acuity and scotopic microperimetry testing, which used the Scotopic Macular Integrity Assessment (S-MAIA) microperimeter. A subset of participants completed repeat scotopic testing to enable Bland-Altman repeatability analyses. Tes

SUBMITTER: Taylor LJ 

PROVIDER: S-EPMC11441449 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature