The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism.

ABSTRACT: Systemic inflammation elicits sickness behaviors and fever by engaging a complex neuronal circuitry that begins in the preoptic area of the hypothalamus. Ectotherms such as teleost fish display sickness behaviors in response to infection or inflammation, seeking warmer temperatures to enhance survival via behavioral fever responses. To date, the hypothalamus is the only brain region implicated in sickness behaviors and behavioral fever in teleosts. Yet, the complexity of neurobehavioral manifestations underlying sickness responses in teleosts suggests engagement of higher processing areas of the brain. Using in vivo models of systemic inflammation in rainbow trout, we find canonical pyrogenic cytokine responses in the hypothalamus whereas in the telencephalon and the optic tectum il-1b<

SUBMITTER: Mani A 

PROVIDER: S-EPMC11441480 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature