Glial <i>swip-10</i> controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis.

ABSTRACT: Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on mitochondrial production of ATP, with many neurodegenerative diseases, including Parkinson's disease, associated with diminished mitochondrial function. The gene MBLAC1 encodes a ribonuclease that targets pre-mRNA of replication-dependent histones, proteins recently found in yeast to reduce Cu(II) to Cu(I), and when mutated disrupt ATP production, elevates oxidative stress, and severely impacts cell growth. Whether this process supports neuronal and/or systemic physiology in higher eukaryotes is unknown. Previously, we identified swip-10, the putative Caenorh

SUBMITTER: Rodriguez P 

PROVIDER: S-EPMC11441482 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature