Neural network architecture of a mammalian brain.

ABSTRACT: Connectomics research is making rapid advances, although models revealing general principles of connectional architecture are far from complete. Our analysis of 10⁶ published connection reports indicates that the adult rat brain interregional connectome has about 76,940 of a possible 623,310 axonal connections between its 790 gray matter regions mapped in a reference atlas, equating to a network density of 12.3%. We examined the sexually dimorphic network using multiresolution consensus clustering that generated a nested hierarchy of interconnected modules/subsystems with three first-order modules and 157 terminal modules in females. Top-down hierarchy analysis suggests a mirror-image primary module pair in the central nervous system's rostral sector (forebrain-midbrain) associa

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC11441483 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature