The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.

ABSTRACT: Androgens exert their effects primarily by binding to the androgen receptor (AR), a ligand-dependent nuclear receptor. While androgens have anabolic effects on skeletal muscle, previous studies reported that AR functions in myofibers to regulate skeletal muscle quality, rather than skeletal muscle mass. Therefore, the anabolic effects of androgens are exerted via nonmyofiber cells. In this context, the cellular and molecular mechanisms of AR in mesenchymal progenitors, which play a crucial role in maintaining skeletal muscle homeostasis, remain largely unknown. In this study, we demonstrated expression of AR in mesenchymal progenitors and found that targeted AR ablation in mesenchymal progenitors reduced limb muscle mass in mature adult, but not young or aged, male mice, although fatty inf

SUBMITTER: Sakai H 

PROVIDER: S-EPMC11441553 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature