Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture during <i>Drosophila</i> ovulation.

ABSTRACT: Ovulation is critical for sexual reproduction and consists of the process of liberating fertilizable oocytes from their somatic follicle capsules, also known as follicle rupture. The mechanical force for oocyte expulsion is largely unknown in many species. Our previous work demonstrated that Drosophila ovulation, as in mammals, requires the proteolytic degradation of the posterior follicle wall and follicle rupture to release the mature oocyte from a layer of somatic follicle cells. Here, we identified actomyosin contraction in somatic follicle cells as the major mechanical force for follicle rupture. Filamentous actin (F-actin) and nonmuscle myosin II (NMII) are highly enriched in the cortex of follicle cells upon stimulation with octopamine (OA), a monoamine critical for Drosop

SUBMITTER: Cho SE 

PROVIDER: S-EPMC11441566 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature