Derivation of Russian-specific reference intervals for complete blood count, iron markers and related vitamins.

ABSTRACT:

Objectives

This study aimed to establish reference intervals (RIs) for Russian adults for hematological parameters including related iron markers and vitamins. Sources of variation of reference values (RVs) and needs for secondary exclusion were explored for proper derivations of RIs.

Methods

Following the harmonized protocol of the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL), 506 healthy Russians (age 18-80; 46% male) were recruited. Complete blood counts (CBC) and leukocyte differentials, iron markers, vitamin B12, and folate were measured by Beckman Coulter's analyzers. Sources of variation were analyzed by multiple regression analysis, and ANOVAs, and the need for partitioning RVs was decided accordingly. Two schemes of excluding latent anemia were

SUBMITTER: Ruzhanskaya A 

PROVIDER: S-EPMC11441669 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature