Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy.

ABSTRACT: Centrosome amplification is a feature of cancer cells associated with chromosome instability and invasiveness. Enhancing chromosome instability and subsequent cancer cell death via centrosome unclustering and multipolar divisions is an aimed-for therapeutic approach. Here, we show that centrosome amplification potentiates responses to conventional chemotherapy in addition to its effect on multipolar divisions and chromosome instability. We perform single-cell live imaging of chemotherapy responses in epithelial ovarian cancer cell lines and observe increased cell death when centrosome amplification is induced. By correlating cell fate with mitotic behaviors, we show that enhanced cell death can occur independently of chromosome instability. We identify that cells with centrosome amplificat

SUBMITTER: Edwards F 

PROVIDER: S-EPMC11441705 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature