HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions.

ABSTRACT:

Background

HCC is a highly vascular tumor, and many effective drug regimens target the tumor blood vessels. Prior bulk HCC subtyping data used bulk transcriptomes, which contained a mixture of parenchymal and stromal contributions.

Methods

We utilized computational deconvolution and cell-cell interaction analyses to cell type-specific (tumor-enriched and vessel-enriched) spatial transcriptomic data collected from 41 resected HCC tissue specimens.

Results

We report that the prior Hoshida bulk transcriptional subtyping schema is driven largely by an endothelial fraction, show an alternative tumor-specific schema has potential prognostic value, and use spatially paired ligand-receptor analyses to identify known and novel (LGALS9 tumor-HAVCR2 vessel) signaling relationshi

SUBMITTER: Lu C 

PROVIDER: S-EPMC11441860 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature