House dust mite-induced asthma exacerbates Alzheimer's disease changes in the brain of the App^NL-G-F mouse model of disease.

ABSTRACT: Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and neuronal death. Besides aging, various comorbidities increase the risk of AD, including obesity, diabetes, and allergic asthma. Epidemiological studies have reported a 2.17-fold higher risk of dementia in asthmatic patients. However, the molecular mechanism(s) underlying this asthma-associated AD exacerbation is unknown. This study was designed to explore house dust mite (HDM)-induced asthma effects on AD-related brain changes using the App^NL-G-F transgenic mouse model of disease. Male and female 8-9 months old C57BL/6J wild type and App^NL-G-F mice were exposed to no treatment, saline sham, or HDM extract every alter

SUBMITTER: Sahu B 

PROVIDER: S-EPMC11442016 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature