Efficacy and safety of intralesional triamcinolone acetonide alone and its combination with 5- fluorouracil in keloids and hypertrophic scars: Randomized, parallel group, and double blinded trial.

ABSTRACT:

Background

Treatment of keloids and hypertrophic scars is challenging. The current first-line treatment is a steroid which has high resistance and recurrence rate along with unacceptable adverse effects. Different studies involving the combination of TAC and 5-FU that have been done so far showed better treatment outcomes in terms of efficacy and safety.

Objective

The objective of this study was to compare the efficacy and safety of intralesional triamcinolone acetonide alone and its combination with 5-fluorouracil in patients with keloids and hypertrophic scars at 12 weeks follow-up.

Methods

In this randomized parallel group double-blinded clinical trial, we enroled 66 cases of keloids and hypertrophic scars randomly allocated into two treatment groups. Patients rece

SUBMITTER: Acharya R 

PROVIDER: S-EPMC11442070 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature