Gout risk in adults with pre-diabetes initiating metformin.

ABSTRACT:

Objective

Despite the strong association between gout and pre-diabetes, the role of metformin in gout among individuals with pre-diabetes remains uncertain. We compared the incidence rates of gout in adults with pre-diabetes starting metformin with those not using antidiabetic treatments.

Methods

We conducted a new-user, propensity score-matched cohort study using electronic health records from an academic health system (2007-2022). Pre-diabetes was defined based on haemoglobin A1c levels. Metformin users were identified and followed from the first metformin prescription date. Non-users of antidiabetic medications were matched to metformin users based on propensity score and the start of follow-up. The primary outcome was incident gout. Cox proportional hazards models estima

SUBMITTER: Marrugo J 

PROVIDER: S-EPMC11442121 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature