Serum insulin-like growth factor-1 as a potential prognostic biomarker for heart failure with reduced ejection fraction: a meta-analysis.

ABSTRACT:

Background

Most studies have indicated that peripheral insulin-like growth levels factor-1 (IGF-1) is valuable in diagnosing heart failure, although the results have been inconsistent. To help solve the debate, we performed a meta-analysis to explore the relationship between IGF-1 and heart failure (HF).

Methods

We conducted an extensive search across various databases such as Embase, Cochrane Library, Pubmed, Medline, and Web of Science on May 30, 2023. From the extensive pool of studies, we selected 16 relevant articles, encompassing a total of 1,380 cases and 1,153 controls, to conduct a rigorous meta-analysis.

Results

The total results indicated that there is an association between lower IGF-1 level and HF. The random-effects model yielded a pooled standardized me

SUBMITTER: Liu T 

PROVIDER: S-EPMC11442213 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature