Combinatorial protection of cochlear hair cells: not too little but not too much.

ABSTRACT:

Background

A number of drugs are toxic to the cochlear sensory cells known as hair cells (HCs), resulting in hearing loss. Treatment with survival-promoting growth factors, antioxidants, and inhibitors of cell death pathways or proteinases have been shown to reduce HC damage in in vivo and/or in vitro animal models. Conversely, translation to humans has often been disappointing. This may be due to the complexity of intracellular damage processes. We hypothesized that combining treatments targeting different cellular processes would be more effective.

Methods

Using an in vitro model of gentamicin ototoxicity for murine cochlear hair cells, we screened all 56 possible combinations of inhibitors targeting five different cell damage mechanisms, plus the acti

SUBMITTER: Kurabi A 

PROVIDER: S-EPMC11442228 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature