NK cells contribute to the resolution of experimental malaria-associated acute respiratory distress syndrome after antimalarial treatment.

ABSTRACT: In both humans and mice, natural killer (NK) cells are important lymphocytes of the innate immune system. They are often considered pro-inflammatory effector cells but may also have a regulatory or pro-resolving function by switching their cytokine profile towards the production of anti-inflammatory cytokines, including interleukin-10 (IL-10) and transforming growth factor-β, and by killing pro-inflammatory immune cells. Here, the role of NK cells in the resolution of malaria lung pathology was studied. Malaria complications, such as malaria-associated acute respiratory distress syndrome (MA-ARDS), are often lethal despite the rapid and efficient killing of Plasmodium parasites with antimalarial drugs. Hence, studying the resolution and healing mechanisms involved in the recovery fr

SUBMITTER: Pollenus E 

PROVIDER: S-EPMC11442241 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature