Spared ulnar nerve injury results in increased layer III-VI excitability in the pig somatosensory cortex.

ABSTRACT: This study describes cortical recordings in a large animal nerve injury model. We investigated differences in primary somatosensory cortex (S1) hyperexcitability when stimulating injured and uninjured nerves and how different cortical layers contribute to S1 hyperexcitability after spared ulnar nerve injury. We used a multielectrode array to record single-neuron activity in the S1 of ten female Danish landrace pigs. Electrical stimulation of the injured and uninjured nerve evoked brain activity up to 3 h after injury. The peak amplitude and latency of early and late peristimulus time histogram responses were extracted for statistical analysis. Histological investigations determined the layer of the cortex in which each electrode contact was placed. Nerve injury increased the early peak amp

SUBMITTER: Meijs S 

PROVIDER: S-EPMC11442301 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature