Monitoring of Leishmania transmission in the postelimination phase: The potential of serological surveys.

ABSTRACT:

Objectives

Monitoring of Leishmania transmission is considered a strategic priority for sustaining elimination of visceral leishmaniasis as a public health problem in the Indian subcontinent. The objective of this study was to evaluate whether serological surveys can distinguish between communities with and without Leishmania transmission, and to assess which serological marker performs best.

Methods

Seven villages were selected from Bihar and Uttar Pradesh state, India, and categorized as either currently endemic (CE), previously endemic (PE) or nonendemic (NE). Blood samples were analyzed with the rK39 RDT, direct agglutination test (DAT), and rK39 ELISA.

Results

Contrary to the rK39 RDT and DAT, the rK39 ELISA showed a significant difference between all three categ

SUBMITTER: Cloots K 

PROVIDER: S-EPMC11442319 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature