MEF2C Alleviates Postoperative Cognitive Dysfunction by Repressing Ferroptosis.

ABSTRACT:

Background

Ferroptosis, a form of programmed cell death featured by lipid peroxidation, has been proposed as a potential etiology for postoperative cognitive dysfunction (POCD). Myocyte-specific enhancer factor 2C (MEF2C), a transcription factor expressed in various brain cell types, has been implicated in cognitive disorders. This study sought to ascertain whether MEF2C governs postoperative cognitive capacity by affecting ferroptosis.

Methods

Transcriptomic analysis of public data was used to identify MEF2C as a candidate differentially expressed gene in the hippocampus of POCD mice. The POCD mouse model was established via aseptic laparotomy under isoflurane anesthesia after treatment with recombinant adeno-associated virus 9 (AAV9)-mediated overexpression of MEF2C and/or

SUBMITTER: Wang S 

PROVIDER: S-EPMC11442332 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature