Trem2 acts as a non-classical receptor of interleukin-4 to promote diabetic wound healing.

ABSTRACT:

Background

The immunoglobulin superfamily protein Trem2 (triggering receptor expressed on myeloid cells 2) is primarily expressed on myeloid cells where it functions to regulate macrophage-related immune response induction. While macrophages are essential mediators of diabetic wound healing, the specific regulatory role that Trem2 plays in this setting remains to be established.

Objective

This study was developed to explore the potential importance of Trem2 signalling in diabetic wound healing and to clarify the underlying mechanisms through which it functions.

Methods and results

Following wound induction, diabetic model mice exhibited pronounced upregulation of Trem2 expression, which was primarily evident in macrophages. No cutaneous defects were evident in mice be

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11442487 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature