Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity.

ABSTRACT:

Introduction

Temporomandibular joint osteoarthritis (TMJ OA) is a major disease that affects maxillofacial health and is characterised by cartilage degeneration and subchondral bone remodelling. Obesity is associated with the exacerbation of pathological manifestations of TMJ OA. However, the underlying mechanism between adipose tissue and the TMJ axis remains limited.

Objectives

To evaluate the effects of obesity and the adipose tissue on the development of TMJ OA.

Methods

The obesity-related metabolic changes in TMJ OA patients were detected by physical signs and plasma metabolites. The effects of adipose tissue-derived EVs (Ad-EVs) on TMJ OA was investigated through histological and cytological experiments as well as gene editing technology. Alterations of Ad-EVs i

SUBMITTER: Li B 

PROVIDER: S-EPMC11442491 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature