A population-scale analysis of 36 gut microbiome studies reveals universal species signatures for common diseases.

ABSTRACT: The gut microbiome has been implicated in various human diseases, though findings across studies have shown considerable variability. In this study, we reanalyzed 6314 publicly available fecal metagenomes from 36 case-control studies on different diseases to investigate microbial diversity and disease-shared signatures. Using a unified analysis pipeline, we observed reduced microbial diversity in many diseases, while some exhibited increased diversity. Significant alterations in microbial communities were detected across most diseases. A meta-analysis identified 277 disease-associated gut species, including numerous opportunistic pathogens enriched in patients and a depletion of beneficial microbes. A random forest classifier based on these signatures achieved high accuracy in distinguishi

SUBMITTER: Sun W 

PROVIDER: S-EPMC11442664 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature