CD226 implicated in Akt-dependent apoptosis of CD4⁺ T cell contributes to asthmatic pathogenesis.

ABSTRACT: Asthma is a chronic airway inflammatory disease in which CD4⁺ T cell dysregulation occurs. Here, we investigated the molecular role and clinical significance of CD226, a costimulatory molecule of T lymphocytes, in the development of allergic asthma. Our results revealed that the expression of CD226 was significantly increased in CD4⁺ effector T cells, especially in T helper (Th) 2 cells and Th17 cells in patients with asthma. Moreover, CD4⁺ T cell-specific Cd226-knockout mice were generated and together with littermates were challenged with ovalbumin (OVA) to establish a model of allergic asthma. We found that CD226 deficiency in CD4⁺ T cells mitigated lung inflammation, IgE production, and eosinophil infiltration and reduced airway remodeling in

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11442704 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature