Young-onset type 2 diabetes mellitus enhances proteinuria, but not glomerular filtration rate decline: A Japanese cohort study.

ABSTRACT:

Aims/introduction

The time course of chronic kidney disease in young-onset type 2 diabetes mellitus remains unclear. We compared the trajectories of proteinuria and estimated glomerular filtration rate (eGFR) decline between young-onset (aged ≤40 years) and late-onset (aged >40 years) type 2 diabetes mellitus in a Japanese multicenter cohort.

Materials and methods

Participants without diabetic kidney disease were divided into two groups according to age at diagnosis: young- and late-onset. The primary endpoint was eGFR <60 mL/min/1.73 m², proteinuria or both. Multivariable Cox proportional hazards were calculated to estimate incidence.

Results

Among 626 participants with type 2 diabetes mellitus, 78 (12.4%) had young-onset and 548 (87.6%) had late-onset dia

SUBMITTER: Saito H 

PROVIDER: S-EPMC11442850 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature