Leptospira interrogans biofilm transcriptome highlights adaption to starvation and general stress while maintaining virulence.

ABSTRACT: Life-threatening Leptospira interrogans navigate a dual existence: surviving in the environment and infecting mammalian hosts. Biofilm formation is presumably an important survival strategy to achieve this process. Understanding the relation between biofilm and virulence might improve our comprehension of leptospirosis epidemiology. Our study focused on elucidating Leptospira's adaptations and regulations involved in such complex microenvironments. To determine the transcriptional profile of Leptospira in biofilm, we compared the transcriptomes in late biofilms and in exponential planktonic cultures. While genes for motility, energy production, and metabolism were downregulated, those governing general stress response, defense against metal stress, and redox homeostasis showed a significan

SUBMITTER: Davignon G 

PROVIDER: S-EPMC11442865 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature