Prognostic value of post-operative iron biomarkers in colorectal cancer: population-based patient cohort.

ABSTRACT:

Background

Post-operative anaemia is linked to iron deficiency. We investigated the prognostic value of post-operative iron biomarkers in colorectal cancer (CRC).

Methods

Ferritin, transferrin, iron, and transferrin saturation (TS%) were measured from blood collected at a single time-point post-surgery in 2769 CRC patients. Associations between iron biomarkers with cancer-specific survival (CSS) and overall survival (OS) were assessed using Cox regression with hazard ratios (HR), stratified by post-operative time of blood collection (<1-month/≥1-month).

Results

After a median follow-up of 9.5 years, 52.6% of patients had died. For iron biomarkers assessed <1-month post-surgery, higher compared to normal TS% was associated with shorter CSS (HR [95% CI] = 2.36 [1.25-4.4

SUBMITTER: Gwenzi T 

PROVIDER: S-EPMC11442944 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature