Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization.

ABSTRACT:

Background

Epilepsy, a complex neurological disorder, is closely linked with structural and functional irregularities in the brain. However, the causal relationship between brain imaging-derived phenotypes (IDPs) and epilepsy remains unclear. This study aimed to investigate this relationship by employing a two-sample bidirectional Mendelian randomization (MR) approach.

Methods

The analysis involved 3935 cerebral IDPs from the UK Biobank and all documented cases of epilepsy (all epilepsies) cohorts from the International League Against Epilepsy, with further validation through replication and meta-analyses using epilepsy Genome-Wide Association Studies datasets from the FinnGen database. Additionally, a multivariate MR analysis framework was utilized to assess the direct impa

SUBMITTER: Li F 

PROVIDER: S-EPMC11442987 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature