SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism.

ABSTRACT: Group-2 innate lymphoid cells (ILC2) are part of a growing family of innate lymphocytes known for their crucial role in both the development and exacerbation of allergic asthma. The activation and function of ILC2s are regulated by various activating and inhibitory molecules, with their balance determining the severity of allergic responses. In this study, we aim to elucidate the critical role of the suppressor molecule signal regulatory protein alpha (SIRPα), which interacts with CD47, in controlling ILC2-mediated airway hyperreactivity (AHR). Our data indicate that activated ILC2s upregulate the expression of SIRPα, and the interaction between SIRPα and CD47 effectively suppresses both ILC2 proliferation and effector function. To evaluate the function of SIRPα in ILC2-mediated AHR, we co

SUBMITTER: Sakano Y 

PROVIDER: S-EPMC11442993 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature