Histopathological comparison of Sjogren-related features between paired labial and parotid salivary gland biopsies of sicca patients.

ABSTRACT:

Objectives

To compare focus score and other histopathological features between paired labial and parotid salivary gland biopsies in a diagnostic cohort of suspected Sjögren's disease (SjD) patients.

Methods

Labial and parotid salivary gland biopsies were simultaneously obtained from patients with sicca complaints, suspected of having SjD. Biopsies were formalin fixed and paraffin embedded. Sections were stained with haematoxylin & eosin, and for CD3, CD20, CD45, cytokeratin, CD21, Bcl6, activation-induced deaminase (AID) and IgA/IgG. Focus score and other histopathological features characteristic for SjD were analysed.

Results

Based on the expert opinion of three experienced rheumatologists, 36 patients were diagnosed as SjD and 63 as non-SjD sicca patients. When taki

SUBMITTER: Nakshbandi U 

PROVIDER: S-EPMC11443036 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature