MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma.

ABSTRACT:

Background

Immune checkpoint blockade is a highly successful anti-cancer immunotherapy. Both CTLA4 and PD1 checkpoint blockers are clinically available for melanoma treatment, with anti-PD1 therapy reaching response rates of 35-40%. These responses, which are mediated via neoantigen presentation by the polymorphic MHC complex, are hard to predict and the tumor mutation burden is currently one of the few available biomarkers. While MHC genotypes are expected to determine therapy responses, association studies have remained largely elusive.

Methods

We developed an overall MHC genotype binding score (MGBS), indicative of a patient's MHC class I (MHC-I) and class II (MHC-II) neoantigen binding capacity and solely based on the germline MHC-I (MGBS-I) and MHC-II (MGBS-II) genotype

SUBMITTER: Claeys A 

PROVIDER: S-EPMC11443121 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature