Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans.

ABSTRACT: Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unc

SUBMITTER: Castro P 

PROVIDER: S-EPMC11443142 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature