Distribution of Acute and Chronic Kidney Disease Across Clinical Phenotypes for Sepsis.

ABSTRACT:

Background

Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients. Four phenotypes (α, β, γ, δ) for sepsis, which have different outcomes and responses to treatment, were described using routine clinical data in the electronic health record.

Research question

Do the frequencies of AKI, acute kidney disease (AKD), chronic kidney disease (CKD), and AKI on CKD differ by sepsis phenotype?

Study design and methods

This was a secondary analysis of a randomized clinical trial of early resuscitation, including patients with septic shock at 31 sites. After excluding patients with end-stage kidney disease and missing data, we determined frequencies of the following clinical outcomes: AKI (defined within 24 h as Kidney Disease: Improving Global O

SUBMITTER: Molinari L 

PROVIDER: S-EPMC11443243 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature