Calibrating Observational Health Record Data Against a Randomized Trial.

ABSTRACT:

Importance

The conditions required for health record data sources to accurately assess treatment effectiveness remain unclear. Emulation of randomized clinical trials (RCTs) with health record data and subsequent calibration of the results can help elucidate this.

Objective

To pilot an emulation of the KEYNOTE-189 RCT using a commercially available electronic health record (EHR) data source.

Design, setting, and participants

This retrospective cohort study used an EHR database spanning from April 2007 to February 2023. Follow-up began on treatment initiation and proceeded until an outcome event, loss to follow-up, end of data, or end of study period (640 days). The population-based cohort was ascertained from EHRs provided by 52 health systems across the US. Eligibili

SUBMITTER: Merola D 

PROVIDER: S-EPMC11443351 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature