Insights into the molecular interactions between urease subunit gamma from MRSA and drugs: <i>an integrative approach by STD-NMR and molecular docking studies</i>.

ABSTRACT: Staphylococcus aureus, an important human pathogen, is developing resistance against a wide range of antibiotics. The antibiotic resistance in S. aureus has created the need to identify new drug targets, and to develop new drugs candidates. In the current study, urease subunit gamma from Methicillin Resistant Staphylococcus aureus (MRSA 252) was studied as a potential drug target, through protein-ligand interactions. Urease is the main virulence factor of MRSA, it catalyzes the conversion of urea into ammonia that is required for the survival of bacteria during acid stress. Its subunits and accessory proteins can serve as targets for drug discovery and development. Present study describes the cloning, expression, and purification of urease subunit gamma from MRSA 252.

SUBMITTER: Fatima A 

PROVIDER: S-EPMC11443414 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature