Visual mismatch negativity in Parkinson's psychosis and potential for testing treatment mechanisms.

ABSTRACT: Psychosis and visual hallucinations are a prevalent non-motor symptom of Parkinson's disease, negatively affecting patients' quality of life and constituting a greater risk for dementia. Understanding neural mechanisms associated to these symptoms is instrumental for treatment development. The mismatch negativity is an event-related potential evoked by a violation in a sequence of sensory events. It is widely considered an index of sensory change-detection. Reduced mismatch negativity response is one of the most replicated results in schizophrenia and has been suggested to be a superior psychosis marker. To understand whether this event-related potential component could be a similarly robust marker for Parkinson's psychosis, we used electroencephalography with a change-detection task to st

SUBMITTER: Vignando M 

PROVIDER: S-EPMC11443450 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature