Reaping the Chemical Diversity of <i>Morinagamyces vermicularis</i> Using Feature-Based Molecular Networking.

ABSTRACT: Moringadepsin (6) and chaetone B (7) were isolated by us in the course of a conventional chemical screening of Morinagamyces vermicularis CBS 303.81, a fungus belonging to the relatively underexplored family Schizotheciaceae of the phylum Ascomycota. Since these metabolites did not account for the antifungal activity observed in a crude extract of this fungus, we utilized an MS/MS-based molecular networking approach to get a thorough insight into the secondary metabolites produced by this strain. Manual annotation of high-resolution fragmentation mass spectra by CANOPUS classified a major molecular family as putatively new thiodiketopiperazines. However, these results were opposite to the results of ChemWalker analysis based solely on MS/MS data, assigning these metabo

SUBMITTER: Harms K 

PROVIDER: S-EPMC11443486 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature